Abstract:
A healthy adult brain has 100 billion nerve cells or neurons with long branching extensions connected at 100 trillion points. At these connections, called synapses, information flows in tiny chemical pulses released by one neuron and taken up by the receiving cell. Different strengths and patterns of signals move constantly through the brain’s circuits, creating the cellular basis of memories, thoughts and skills. During Alzheimer’s Disease (AD) - a late-onset, progressive, age-dependent neurodegenerative disorder, characterized clinically by the impairment of cognitive functions and changes in behavior and personality - information transfer at the synapses begins to fail, the number of synapses decline and eventually cells die. A fundamental problem in AD is the aberrant generation of amyloidogenic ß-amyloid peptides in the brain possibly by abnormal processing of Amyloid Precursor Protein leading to abnormal deposition of neuritic plaques, which is a neuropathological hallmark of AD. The goal of our research is to elucidate the biochemical mechanism behind the AD pathology. In recent years we are focusing on triggering innate mechanisms to promote neurogenesis as a way of treatment against AD and other diseases like Cerebral Stroke.
Keywords: Alzheimer’s Disease, Cerebral Stroke, Neurogenesis
A healthy adult brain has 100 billion nerve cells or neurons with long branching extensions connected at 100 trillion points. At these connections, called synapses, information flows in tiny chemical pulses released by one neuron and taken up by the receiving cell. Different strengths and patterns of signals move constantly through the brain’s circuits, creating the cellular basis of memories, thoughts and skills. During Alzheimer’s Disease (AD) - a late-onset, progressive, age-dependent neurodegenerative disorder, characterized clinically by the impairment of cognitive functions and changes in behavior and personality - information transfer at the synapses begins to fail, the number of synapses decline and eventually cells die. A fundamental problem in AD is the aberrant generation of amyloidogenic ß-amyloid peptides in the brain possibly by abnormal processing of Amyloid Precursor Protein leading to abnormal deposition of neuritic plaques, which is a neuropathological hallmark of AD. The goal of our research is to elucidate the biochemical mechanism behind the AD pathology. In recent years we are focusing on triggering innate mechanisms to promote neurogenesis as a way of treatment against AD and other diseases like Cerebral Stroke.
Keywords: Alzheimer’s Disease, Cerebral Stroke, Neurogenesis
Introduction:
What is Alzheimer's Disease? What is Ischemic Stroke?
What is Alzheimer's Disease? What is Ischemic Stroke?
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Projects
Sl. no. |
Funding Agency |
Title of the Research Project |
Period |
Role |
1 |
DBT |
Do Mitochondrial dysfunction provide possible grounds for amyloid (Aβ42) formation during aging– Intervention of sirutins in counteracting multiple stage pathophysiology: with special reference to Alzheimer’s Disease |
2011-2014 |
PI |
2 |
DST |
Does SIR proteins attenuate Alzheimer’s Disease (AD) pathogenesis by regulating cholesterol homeostasis – An approach to understand the biochemical concept behind AD pathology |
2012-2015 |
PI |
3 |
UGC |
Identification of the intracellular localization of α, β and γ-secretase and APP cleavage pattern in young and aged rat brain regions: An understanding towards the underlying mechanism behind AD pathophysiology |
2012-2015 |
PI |
4 |
ICMR |
Hyperinsulinemia influences autophagy and mitochondrial biogenesis: A possible mechanism of neuronal ageing |
2013-2016 |
Co-PI |
5 |
DST-SERB |
Assessment of the effect of aspirin treatment on brain regeneration |
2018-2021 |
Co-PI |
6 |
ICMR |
Experimental study on brain regeneration and functional recovery after stroke. |
2019-2022 |
PI |
7 |
DST-CSRI |
Investigating the role of resveratrol in regulating cognitive impairment during Alzheimer's Disease. |
2020-2024 |
PI |
8 |
RUSA 2.0 |
Elucidating the role of small compounds in rat model for Alzheimer’s Disease |
2021-2024 |
PI |